Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate

Base Information

• Chemical Name: Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate
• CAS No.: 95407-39-9
• Molecular Formula: C₁₆H₂₀N₂O₄
• Molecular Weight: 304.346
• Mol file: 95407-39-9.mol

Synonyms:Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate

Chemical Property of Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate

There total 5 articles about Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-[(1,1-dimethylethoxycarbonyl)amino]-L-asparagine benzyl ester (13512-57-7) → Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate (95407-39-9)

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; In dichloromethane; for 48h;

DOI:10.1021/jo00208a017

Reference yield:

N-tert-butyloxycarbonylasparagine (7536-55-2) + benzyl alcohol (100-51-6,185532-71-2) → Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate (95407-39-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 12h; Solvent; Inert atmosphere;

DOI:10.1055/s-0035-1560489

Reference yield:

N-tert-butyloxycarbonylasparagine (7536-55-2) + benzyl alcohol (100-51-6,185532-71-2) → N-[(1,1-dimethylethoxycarbonyl)amino]-L-asparagine benzyl ester (13512-57-7) + Benzyl 2(S)-<(tert-butoxycarbonyl)amino>-3-cyanopropionate (95407-39-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0035-1560489

upstream raw materials:

N-[(1,1-dimethylethoxycarbonyl)amino]-L-asparagine benzyl ester

P-toluenesulfonyl cyanide

(R)-N-(tert-butoxycarbonyl)-3-iodoalanine benzyl ester

di-tert-butyl dicarbonate

Downstream raw materials:

3-cyanoalanine benzyl ester