4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile

Base Information

Chemical Name:4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile
CAS No.:1351372-25-2
Molecular Formula:C₂₅H₂₄FN₃O
Molecular Weight:401.483
Hs Code.:

Synonyms:4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile

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Chemical Property of 4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile

Chemical Property:

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Technology Process of 4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile

There total 6 articles about 4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-chloromethylpyridine-2-carbonitrile

: 189346-58-5
4-[(4-fluorophenyl)phenylmethoxy]piperidine

: 1351372-25-2
4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 71935-32-5
2-Cyano-4-(hydroxymethyl)pyridine

: 1351372-25-2
4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 0.5 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 70 °C

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 586-95-8
pyridine-4-methanol

: 1351372-25-2
4-{4-[(4-fluorophenyl)phenylmethoxy]piperidino-1-ylmethyl}pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3: triethylamine / triethylamine / 3 h / 90 °C / Inert atmosphere

4: sulfuric acid / ethanol / Reflux

5: thionyl chloride / toluene / 0.5 h / Reflux

6: potassium carbonate / N,N-dimethyl-formamide / 70 °C

With 1H-imidazole; thionyl chloride; sulfuric acid; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; triethylamine; N,N-dimethyl-formamide; toluene;