5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

Base Information

Chemical Name:5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid
CAS No.:269411-95-2
Molecular Formula:C₂₉H₃₂O₅Si
Molecular Weight:488.656
Hs Code.:

Synonyms:5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

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Chemical Property of 5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

Chemical Property:

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Technology Process of 5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

There total 6 articles about 5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 269411-93-0
5-(tert-butyl-diphenyl-silanyloxymethyl)-5-formyl-benzoic acid

: 269411-95-2
5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

5-(tert-butyl-diphenyl-silanyloxymethyl)-5-formyl-benzoic acid; In N,N-dimethyl-formamide; at 0 - 23 ℃; Further stages.;
DOI:10.1021/jm9903242

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 269411-95-2
5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 39.9 g / imidazole / dimethylformamide / 23 °C

2.1: 87 percent / 0.95 N aq. NaOH / 72 h / 23 °C

3.1: 26.8 g / lithium triethylborohydride / tetrahydrofuran / 23 °C

4.1: 21.0 g / NMO; 3A molecular sieves; TPAP / CH₂Cl₂ / 2 h / 23 °C

5.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C

5.2: dimethylformamide / 0 - 23 °C

With 1H-imidazole; sodium hydroxide; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 3 A molecular sieve; sodium hydride; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: silylation / 2.1: methanolysis / 3.1: Reduction / 4.1: Oxidation / 5.1: Metallation / 5.2: Substitution;
DOI:10.1021/jm9903242

Reference yield:

: 181425-91-2
diethyl 5-(hydroxymethyl)isophthalate

: 269411-95-2
5-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-ethoxycarbonyl-vinyl)-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 39.9 g / imidazole / dimethylformamide / 23 °C

2.1: 87 percent / 0.95 N aq. NaOH / 72 h / 23 °C

3.1: 26.8 g / lithium triethylborohydride / tetrahydrofuran / 23 °C

4.1: 21.0 g / NMO; 3A molecular sieves; TPAP / CH₂Cl₂ / 2 h / 23 °C

5.1: sodium hydride / dimethylformamide / 0.5 h / 0 °C

5.2: dimethylformamide / 0 - 23 °C

With 1H-imidazole; sodium hydroxide; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 3 A molecular sieve; sodium hydride; lithium triethylborohydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: silylation / 2.1: methanolysis / 3.1: Reduction / 4.1: Oxidation / 5.1: Metallation / 5.2: Substitution;
DOI:10.1021/jm9903242