ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-4,4,4-trifluorobutanoate

Base Information

Chemical Name:ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-4,4,4-trifluorobutanoate
CAS No.:1219366-65-0
Molecular Formula:C₁₇H₁₉F₃N₂O₄
Molecular Weight:372.344
Hs Code.:

Synonyms:ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-4,4,4-trifluorobutanoate

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Chemical Property of ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-4,4,4-trifluorobutanoate

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Technology Process of ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-4,4,4-trifluorobutanoate

There total 3 articles about ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-4,4,4-trifluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1219366-95-6
4-(but-2-yn-1-yloxy)benzoyl chloride

: 1219366-64-9
ethyl (2S,3R)-2,3-diamino-4,4,4-trifluorobutanoate

: 1219366-65-0
ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-4,4,4-trifluorobutanoate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 36h;
DOI:10.1021/acs.jmedchem.7b00377

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1219366-65-0
ethyl (2S,3R)-3-amino-2-(4-(but-2-yn-1-yloxy)benzamido)-4,4,4-trifluorobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 0 - 20 °C

2.1: potassium hydroxide / water; methanol; tetrahydrofuran / 24 h / 20 °C

3.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / Reflux

With thionyl chloride; sodium hydride; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.7b00377