methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate

Base Information

Chemical Name:methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate
CAS No.:1349199-66-1
Molecular Formula:C₂₅H₂₃BrFNO₃
Molecular Weight:484.365
Hs Code.:

Synonyms:methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate

Suppliers and Price of methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate

There total 1 articles about methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 885068-47-3
methyl 2-(5-bromo-2-fluorophenyl)acetate

: 40320-60-3
N-benzhydryl 3-azetidinone

: 1349199-66-1
methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate

Guidance literature:: methyl 2-(5-bromo-2-fluorophenyl)acetate; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.333333h; Inert atmosphere;

N-benzhydryl 3-azetidinone; In tetrahydrofuran; hexanes; at -78 - -20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol2028459

Reference yield: 60.0%

: 1349199-66-1
methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate

: 1349199-67-2
1-benzhydryl-3-(1-(5-bromo-2-fluorophenyl)-2-hydroxyethyl)azetidin-3-ol

Guidance literature:: methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 5h;

With water; sodium hydroxide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol2028459

Reference yield:

: 1349199-66-1
methyl 2-(1-benzhydryl-3-hydroxyazetidin-3-yl)-2-(5-bromo-2-fluorophenyl)acetate

: 1349199-68-3
6-benzhydryl-3-(5-bromo-2-fluorophenyl)-1-oxa-6-azaspiro[3.3]heptane

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 5 h / 0 °C

2: potassium tert-butylate; p-toluenesulfonyl chloride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium tert-butylate; p-toluenesulfonyl chloride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol2028459