4-Isoxazolecarboxylicacid,5-(1-hydroxyethyl)-3-phenyl-,ethylester(9CI)

Base Information

• Chemical Name: 4-Isoxazolecarboxylicacid,5-(1-hydroxyethyl)-3-phenyl-,ethylester(9CI)
• CAS No.: 95104-45-3
• Molecular Formula: C14H15 N O4
• Molecular Weight: 261.27
• Hs Code.: 2934999090
• Mol file: 95104-45-3.mol

Synonyms:4-Isoxazolecarboxylicacid,5-(1-hydroxyethyl)-3-phenyl-,ethylester(9CI)

Chemical Property of 4-Isoxazolecarboxylicacid,5-(1-hydroxyethyl)-3-phenyl-,ethylester(9CI)

Chemical Property:

• PSA: 72.56000
• LogP: 2.57160

Purity/Quality:

Ethyl 5-(1-hydroxyethyl)-3-phenylisoxazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isoxazolecarboxylicacid,5-(1-hydroxyethyl)-3-phenyl-,ethylester(9CI)

There total 1 articles about 4-Isoxazolecarboxylicacid,5-(1-hydroxyethyl)-3-phenyl-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methyl-2 ethoxycarbonyl-4 phenyl-5 <2H>-furannone-3 (53252-39-4) → ethyl 5-(1-hydroxyethyl)-3-phenylisoxazole-4-carboxylate (95104-45-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol; for 1h; Heating;

DOI:10.1055/s-1984-31002

Reference yield: 57.0%

ethyl 5-(1-hydroxyethyl)-3-phenylisoxazole-4-carboxylate (95104-45-3) → 5-Acetyl-3-phenyl-isoxazole-4-carboxylic acid ethyl ester (129663-15-6)

Guidance literature:

With jones' reagent; In acetone; for 4h; Ambient temperature;

Reference yield:

ethyl 5-(1-hydroxyethyl)-3-phenylisoxazole-4-carboxylate (95104-45-3) → 4-Benzoyl-5-hydroxy-6-methyl-2H-pyridazin-3-one (129663-35-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / Jones' reagent / acetone / 4 h / Ambient temperature

2: 79 percent / hydrazine hydrate / ethanol / 4 h / Ambient temperature

3: 1) hydrogen, 2) aq. KOH / 1) Pd/C / 1) ethyl acetate, ethanol, ca. 1 atm, RT, 2) 10 min, reflux

With potassium hydroxide; jones' reagent; hydrogen; hydrazine hydrate; palladium on activated charcoal; In ethanol; acetone;

upstream raw materials:

methyl-2 ethoxycarbonyl-4 phenyl-5 <2H>-furannone-3

Downstream raw materials:

5-Acetyl-3-phenyl-isoxazole-4-carboxylic acid ethyl ester

4-Benzoyl-5-hydroxy-6-methyl-2H-pyridazin-3-one

7-Methyl-3-phenyl-5H-isoxazolo[4,5-d]pyridazin-4-one

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