3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin

Base Information

• Chemical Name: 3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin
• CAS No.: 401947-35-1
• Molecular Formula: C₄₅H₇₃N₅O₂₀
• Molecular Weight: 1004.1
• Mol file: 401947-35-1.mol

Synonyms:3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin

Chemical Property of 3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin

There total 4 articles about 3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) + 6'-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin (67987-06-8) → 3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin (401947-35-1)

Guidance literature:

In 1,4-dioxane; water; at 60 ℃;

DOI:10.1002/1521-4184(200109)334:8/9<295::AID-ARDP295>3.0.CO;2-3

Reference yield:

N-(t-butoxycarbonyloxy)-5-norbornene-endo-2,3-dicarboximide → 3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin (401947-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Cu(OAc)2*H₂O / dimethylsulfoxide / 0.5 h / 20 °C

1.2: dimethylsulfoxide / 20 °C

1.3: 83 percent / Na₂S*9H₂O / methanol; H₂O / 0.75 h / 20 °C

2.1: 65 percent / dioxane; H₂O / 20 °C

3.1: 80 percent / dioxane; H₂O / 60 °C

With copper diacetate; In 1,4-dioxane; water; dimethyl sulfoxide;

DOI:10.1002/1521-4184(200109)334:8/9<295::AID-ARDP295>3.0.CO;2-3

Reference yield:

isepamicin (58152-03-7) → 3,6',3''-tri-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin (401947-35-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Cu(OAc)2*H₂O / dimethylsulfoxide / 0.5 h / 20 °C

1.2: dimethylsulfoxide / 20 °C

1.3: 83 percent / Na₂S*9H₂O / methanol; H₂O / 0.75 h / 20 °C

2.1: 65 percent / dioxane; H₂O / 20 °C

3.1: 80 percent / dioxane; H₂O / 60 °C

With copper diacetate; In 1,4-dioxane; water; dimethyl sulfoxide;

DOI:10.1002/1521-4184(200109)334:8/9<295::AID-ARDP295>3.0.CO;2-3

upstream raw materials:

di-tert-butyl dicarbonate

6'-N-(t-butoxycarbonyl)-3'''-N-(benzyloxycarbonyl)isepamicin

isepamicin

6'-N-(t-butoxycarbonyl)-isepamicin

Downstream raw materials:

3,6',3''-tri-N-(t-butoxycarbonyl)-isepamicin