33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin

Base Information

Chemical Name:33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin
CAS No.:307953-32-8
Molecular Formula:C₅₅H₉₇NO₁₁Si₂
Molecular Weight:1004.55
Hs Code.:

Synonyms:33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin

Suppliers and Price of 33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin

Chemical Property:

Purity/Quality:

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Technology Process of 33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin

There total 3 articles about 33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 617-86-7
triethylsilane

: 142498-46-2
12-{2-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-vinyl}-17-ethyl-1-hydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0^4,9]octacosa-14,18-diene-2,3,10,16-tetraone

: 134226-79-2
33-(tert-butyldimethylsilyl)-24-deoxy-ascomycin

: 307953-32-8
33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin

Guidance literature:: With Wilkinson's catalyst; In benzene; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(00)00669-4

Reference yield: 25.0%

: 617-86-7
triethylsilane

: 142498-46-2
12-{2-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-vinyl}-17-ethyl-1-hydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0^4,9]octacosa-14,18-diene-2,3,10,16-tetraone

: 307953-32-8
33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin

: 12-{2-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-vinyl}-17-ethyl-1-hydroxy-23,25-dimethoxy-13,21,27-trimethyl-19-methylene-16-triethylsilanyloxy-11,28-dioxa-4-aza-tricyclo[22.3.1.0^4,9]octacos-15-ene-2,3,10-trione

Guidance literature:: With Wilkinson's catalyst; In benzene; for 1h; Heating;
DOI:10.1016/S0040-4020(00)00669-4

Reference yield:

: 133941-74-9
33-O-(tert-butyldimethylsilyl)-ascomycin

: 307953-32-8
33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonyl chloride; 4-dimethylaminopyridine

2: 55 percent / tris(triphenylphosphine)chlororhodium / benzene / 24 h / 20 °C

With dmap; Wilkinson's catalyst; methanesulfonyl chloride; In benzene; 1: Dehydration / 2: Addition;
DOI:10.1016/S0040-4020(00)00669-4