4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole

Base Information

• Chemical Name: 4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole
• CAS No.: 443755-37-1
• Molecular Formula: C₁₉H₁₉ClN₃O₅P
• Molecular Weight: 435.804
• Mol file: 443755-37-1.mol

Synonyms:4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole

Chemical Property of 4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole

There total 2 articles about 4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-methyl-benzoyl chloride (874-60-2) + [2-(4-chloro-phenyl)-5-hydrazino-oxazol-4-yl]-phosphonic acid dimethyl ester (443755-35-9) → 4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole (443755-37-1)

Guidance literature:

With triethylamine; In acetonitrile; at 20 - 25 ℃;

DOI:10.1023/A:1013935601475

Reference yield:

[2,2,2-trichloro-1-(4-chloro-benzoylamino)-ethyl]-phosphonic acid dimethyl ester → 4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole (443755-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / NH₂NH₂*H₂O / tetrahydrofuran / 72 h / 20 - 25 °C

2: 74 percent / Et₃N / acetonitrile / 48 h / 20 - 25 °C

With hydrazine hydrate; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1023/A:1013982122431

Reference yield: 86.0%

4-dimethoxyphosphoryl-5-(2-p-toluoylhydrazino)-2-p-chlorophenyloxazole (443755-37-1) → 2-[dimethoxyphosphoryl(p-chlorobenzoylamino)]methyl-5-p-tolyl-1,3,4-oxadiazole

Guidance literature:

In ethanol; for 0.5h; Heating;

DOI:10.1023/A:1013935601475

upstream raw materials:

4-methyl-benzoyl chloride

[2-(4-chloro-phenyl)-5-hydrazino-oxazol-4-yl]-phosphonic acid dimethyl ester