2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide

Base Information

• Chemical Name: 2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide
• CAS No.: 352285-40-6
• Molecular Formula: C₂₂H₂₈N₄O₃S
• Molecular Weight: 428.555

Synonyms:2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide

Chemical Property of 2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide

Chemical Property:

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Technology Process of 2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide

There total 3 articles about 2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{3-[tert-butoxycarbonyl-({[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-carbamoyl}-methyl)-amino]-propyl}-carbamic acid tert-butyl ester (352285-39-3) → 2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide (352285-40-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ja010249w

Reference yield:

N,N'-bis(tert-butoxycarbonyl)-(3-aminopropyl)-glycine (192124-66-6) → 2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide (352285-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: EDC; DMAP / CH₂Cl₂ / 0 - 20 °C

2: TFA / CH₂Cl₂ / 2 h / 20 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja010249w

Reference yield:

N,N'-bis(tert-butoxycarbonyl)-(3-aminopropyl)-glycine ethyl ester (352284-59-4) → 2-(3-amino-propylamino)-N-[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-acetamide (352285-40-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / aq. KOH / methanol / 2 h / 20 °C

2: EDC; DMAP / CH₂Cl₂ / 0 - 20 °C

3: TFA / CH₂Cl₂ / 2 h / 20 °C

With dmap; potassium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/ja010249w

upstream raw materials:

{3-[tert-butoxycarbonyl-({[(1-methanesulfonyl-1H-indol-2-yl)-m-tolyl-methyl]-carbamoyl}-methyl)-amino]-propyl}-carbamic acid tert-butyl ester

N,N'-bis(tert-butoxycarbonyl)-(3-aminopropyl)-glycine

N,N'-bis(tert-butoxycarbonyl)-(3-aminopropyl)-glycine ethyl ester

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