methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate

Base Information

Chemical Name:methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate
CAS No.:1357495-93-2
Molecular Formula:C₁₇H₁₇NO₅S
Molecular Weight:347.392
Hs Code.:

Synonyms:methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate

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Chemical Property of methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate

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Technology Process of methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate

There total 3 articles about methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1357495-90-9
methyl 7-oxo-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 1357495-93-2
methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate

Guidance literature:: methyl 7-oxo-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate; With sodium hydroxide; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

p-toluenesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 5.2h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.12.013

Reference yield:

: 208928-20-5
methyl 2-methoxy-4-[(trimethylsilyl)oxy]cyclohex-3-ene-1-carboxylate

: 1357495-93-2
methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc(II) chloride / dichloromethane / 1.33 h / 0 °C / Inert atmosphere

2.1: sodium hydride / diethyl ether; dimethyl sulfoxide / 0.17 h / 0 °C / Inert atmosphere

2.2: 4 h / 0 - 20 °C / Inert atmosphere

2.3: 0.33 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 5.2 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; sodium hydroxide; zinc(II) chloride; In diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2011.12.013

Reference yield:

: 67201-30-3
methyl 4-oxocyclohex-2-ene-1-carboxylate

: 1357495-93-2
methyl 7-oxo-2-p-toluenesulfonyl-4,5,6,7-tetrahydro-2H-isoindole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / diethyl ether; dimethyl sulfoxide / 0.17 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

1.3: 0.33 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2.2: 5.2 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; sodium hydroxide; In diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2011.12.013