S-4-[[(2-Methylbenzyl)amino]carbonyl]oxybenzyl piperazine-1-thiocarboxylate hydrochloride

Base Information

• Chemical Name: S-4-[[(2-Methylbenzyl)amino]carbonyl]oxybenzyl piperazine-1-thiocarboxylate hydrochloride
• CAS No.: 438047-15-5
• Molecular Formula: C₂₁H₂₅N₃O₃S*ClH
• Molecular Weight: 435.975
• Mol file: 438047-15-5.mol

Synonyms:S-4-[[(2-Methylbenzyl)amino]carbonyl]oxybenzyl piperazine-1-thiocarboxylate hydrochloride

Chemical Property of S-4-[[(2-Methylbenzyl)amino]carbonyl]oxybenzyl piperazine-1-thiocarboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-4-[[(2-Methylbenzyl)amino]carbonyl]oxybenzyl piperazine-1-thiocarboxylate hydrochloride

There total 2 articles about S-4-[[(2-Methylbenzyl)amino]carbonyl]oxybenzyl piperazine-1-thiocarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.1%

S-4-hydroxybenzyl 4-tert-butoxycarbonylpiperazine-1-thiocarboxylate (438049-39-9) + R-(+)-methylbenzyl isocyanate (56651-58-2) → S-4-[[(2-Methylbenzyl)amino]carbonyl]oxybenzyl piperazine-1-thiocarboxylate hydrochloride (438047-15-5)

Guidance literature:

Reference yield:

[(4-tert-butyl-dimethylsilyloxy)benzylsulfanylcarbonyl]-piperazine-4-carboxylic acid tert-butyl ester (438049-38-8) → S-4-[[(2-Methylbenzyl)amino]carbonyl]oxybenzyl piperazine-1-thiocarboxylate hydrochloride (438047-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

upstream raw materials:

S-4-hydroxybenzyl 4-tert-butoxycarbonylpiperazine-1-thiocarboxylate

R-(+)-methylbenzyl isocyanate

[(4-tert-butyl-dimethylsilyloxy)benzylsulfanylcarbonyl]-piperazine-4-carboxylic acid tert-butyl ester