C₁₇H₁₈NBrO₃

Base Information

• Chemical Name: C₁₇H₁₈NBrO₃
• CAS No.: 947494-85-1
• Molecular Formula: C₁₇H₁₈BrNO₃
• Molecular Weight: 364.239
• Mol file: 947494-85-1.mol

Synonyms:C₁₇H₁₈NBrO₃

Chemical Property of C₁₇H₁₈NBrO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₇H₁₈NBrO₃

There total 2 articles about C₁₇H₁₈NBrO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C25H25NPO6Br (947494-80-6) + fur-2-ylboronic acid (13331-23-2) → C17H18NBrO3 (947494-85-1)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1021/ol071312a

Reference yield:

C13H16BrNO3 (947494-79-3) → C17H18NBrO3 (947494-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hexamethyldisilazide / tetrahydrofuran; hexamethylphosphoric acid triamide; toluene / 0.5 h / -78 °C

2: 100 percent / cesium carbonate / tetrakis(triphenylphosphine)palladium / dimethylformamide; H₂O / 50 °C

With potassium hexamethylsilazane; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; N,N-dimethyl-formamide; toluene; 2: Suzuki-Miyaura cross-coupling;

DOI:10.1021/ol071312a

Reference yield: 63.0%

C17H18NBrO3 (947494-85-1) → tert-butyl 2-(thiophen-2-yl)-1H-indole-1-carboxylate + 2-(2-thienyl)indole (55968-16-6)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1021/ol071312a

upstream raw materials:

C₂₅H₂₅NPO₆Br

fur-2-ylboronic acid

C₁₃H₁₆BrNO₃

Downstream raw materials:

2-(2-thienyl)indole