N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

Base Information

Chemical Name:N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide
CAS No.:439803-79-9
Molecular Formula:C₃₀H₃₆N₂O₅
Molecular Weight:504.626
Hs Code.:

Synonyms:N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

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Chemical Property of N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

Chemical Property:

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Technology Process of N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

There total 3 articles about N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 439802-32-1
3-(5-{2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy}-3,4-dihydronaphthalen-1-yl)propanoic acid

: 103491-33-4
O-2-methoxypropane 2-hydroxylamine

: 439803-79-9
N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 3-(5-hydroxy-3,4-dihydronaphthalen-1-yl)propanoic acid

: 439803-79-9
N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 0.33 h / -10 °C

1.2: 1 h / -10 - 20 °C

2.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / dichloromethane / 3 h / 20 °C

3.1: methanol; sodium hydroxide; water / tetrahydrofuran / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

With methanol; sodium hydroxide; thionyl chloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 3-methoxycarbonyl-2-(4-methylbenzoylamino)propanoic acid

: 439803-79-9
N-(1-methyl-1-methoxyethoxy)-3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; dmap / 1 h / 90 °C

2.1: sulfuric acid / acetic anhydride / 1 h / 90 °C

2.2: 0 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

4.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / dichloromethane / 3 h / 20 °C

5.1: methanol; sodium hydroxide; water / tetrahydrofuran / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

With pyridine; methanol; dmap; sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; dichloromethane; acetic anhydride; N,N-dimethyl-formamide;