(3aS,4R,6S,6aR,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione

Base Information

Chemical Name:(3aS,4R,6S,6aR,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione
CAS No.:1235239-64-1
Molecular Formula:C₁₈H₁₅F₃O₃
Molecular Weight:336.311
Hs Code.:

Synonyms:(3aS,4R,6S,6aR,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione

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Chemical Property of (3aS,4R,6S,6aR,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione

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Technology Process of (3aS,4R,6S,6aR,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione

There total 2 articles about (3aS,4R,6S,6aR,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 402-50-6
1-trifluoromethyl-4-vinyl-benzene

: 129-64-6
3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

: (3aR,4S,6R,6aS,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione

: 1235239-64-1
(3aS,4R,6S,6aR,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione

: 4-(4-(trifluoromethyl)styryl)-6-vinyltetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione

Guidance literature:: With C₃₅H₄₄Cl₂N₂O₃Ru; In tetrahydrofuran; at 35 ℃; for 40h; Overall yield = 41 percent; Overall yield = 28 mg; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1021/jacs.0c10705

Reference yield:

: 402-50-6
1-trifluoromethyl-4-vinyl-benzene

: 129-64-6
3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride

: (3aR,4S,6R,6aS,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione

: 1235239-64-1
(3aS,4R,6S,6aR,E)-4-[2-(4-trifluoromethyl-phenyl)-vinyl]-6-vinyl-tetrahydro-cyclopenta[c]furan-1,3-dione

Guidance literature:: With [ruthenium(dichloride)(CHC₆H₄OiPr)(C₃H₃N₂(C₆H₃(CH₃)3)(C₆H₄Ph)iPr)]; In dichloromethane; at 25 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201000940