perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate

Base Information

Chemical Name:perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate
CAS No.:1450923-19-9
Molecular Formula:C₂₁H₁₀ClF₈NO₄S
Molecular Weight:559.821
Hs Code.:

Synonyms:perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate

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Chemical Property of perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate

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Technology Process of perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate

There total 1 articles about perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 1450923-18-8
4-(2-chloro-4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride

: 1450923-19-9
perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 163133-86-6,163133-87-7,176772-96-6,176773-06-1,176773-07-2,176799-58-9,591-54-8
pyrimidin-4-amine

: 1450923-19-9
perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate

: 1450919-83-1
4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(pyrimidin-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: pyrimidin-4-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate; In tetrahydrofuran; at -78 - 20 ℃; for 0.666667h;

Reference yield:

: 1450923-19-9
perfluorophenyl 4-[2-chloro-4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonate

: 1450923-41-7
tert-butyl 4-(2-(7-(N-(pyrimidin-4-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 0.67 h / -78 - 20 °C

2.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium phosphate / water; 1,4-dioxane / 3 h / 115 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water;