(R)-2-((R)-2-((S)-2-(((R)-2-(2-(3-aminopropyl)phenoxy)propyl)-amino)-2-cyclopropyl-N-methylacetamido)propanamido)-3-(4-fluorophenyl)propanoic acid

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Chemical Name:(R)-2-((R)-2-((S)-2-(((R)-2-(2-(3-aminopropyl)phenoxy)propyl)-amino)-2-cyclopropyl-N-methylacetamido)propanamido)-3-(4-fluorophenyl)propanoic acid
CAS No.:874336-42-2
Molecular Formula:C₃₀H₄₁FN₄O₅
Molecular Weight:556.678
Hs Code.:

Synonyms:(R)-2-((R)-2-((S)-2-(((R)-2-(2-(3-aminopropyl)phenoxy)propyl)-amino)-2-cyclopropyl-N-methylacetamido)propanamido)-3-(4-fluorophenyl)propanoic acid

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Chemical Property of (R)-2-((R)-2-((S)-2-(((R)-2-(2-(3-aminopropyl)phenoxy)propyl)-amino)-2-cyclopropyl-N-methylacetamido)propanamido)-3-(4-fluorophenyl)propanoic acid

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Technology Process of (R)-2-((R)-2-((S)-2-(((R)-2-(2-(3-aminopropyl)phenoxy)propyl)-amino)-2-cyclopropyl-N-methylacetamido)propanamido)-3-(4-fluorophenyl)propanoic acid

There total 16 articles about (R)-2-((R)-2-((S)-2-(((R)-2-(2-(3-aminopropyl)phenoxy)propyl)-amino)-2-cyclopropyl-N-methylacetamido)propanamido)-3-(4-fluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 49606-99-7,5687-71-8,15785-26-9,49607-01-4
(S)-2-amino-2-cyclopropylacetic acid

: 874336-42-2
(R)-2-((R)-2-((S)-2-(((R)-2-(2-(3-aminopropyl)phenoxy)propyl)-amino)-2-cyclopropyl-N-methylacetamido)propanamido)-3-(4-fluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: methanol / 0 - 20 °C / Inert atmosphere

2: sodium carbonate / water / 20 °C / Inert atmosphere

3: sodium carbonate; potassium iodide / N,N-dimethyl-formamide / 100 °C / Inert atmosphere

4: sodium carbonate / tetrahydrofuran; water / 24 h / 20 °C / Inert atmosphere

5: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

6: N,N-diethyl-N-isopropylamine; HATU / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

7: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / Inert atmosphere

8: hydrogenchloride / 1,4-dioxane; water / 1.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; lithium hydroxide monohydrate; N,N-diethyl-N-isopropylamine; palladium 10% on activated carbon; hydrogen; sodium carbonate; HATU; potassium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm2007062

Reference yield:

: 18125-46-7
(R)-4-fluorophenylalanine

: 874336-42-2
(R)-2-((R)-2-((S)-2-(((R)-2-(2-(3-aminopropyl)phenoxy)propyl)-amino)-2-cyclopropyl-N-methylacetamido)propanamido)-3-(4-fluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Inert atmosphere; Reflux

2: N,N-diethyl-N-isopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 6-chloro-1-hydroxybenzotriazole / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

4: N,N-diethyl-N-isopropylamine; HATU / tetrahydrofuran; dichloromethane / 0 - 20 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane; water / 1.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; N,N-diethyl-N-isopropylamine; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 6-chloro-1-hydroxybenzotriazole; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm2007062