Technology Process of 6-(2,4-difluorophenylamino)-2-(methylthio)nicotinonitrile
There total 4 articles about 6-(2,4-difluorophenylamino)-2-(methylthio)nicotinonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,4-dioxane;
at 100 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; lithium hydroxide monohydrate / ethanol / 2 h / 60 °C
1.2: pH 1
2.1: diphenylether / 4 h / 250 °C
3.1: potassium tert-butylate / tetrahydrofuran / 2.75 h / 20 °C / Inert atmosphere
4.1: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere
With
lithium hydroxide monohydrate; potassium tert-butylate; water; caesium carbonate;
(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; 1,4-dioxane; diphenylether; ethanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diphenylether / 4 h / 250 °C
2: potassium tert-butylate / tetrahydrofuran / 2.75 h / 20 °C / Inert atmosphere
3: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere
With
potassium tert-butylate; caesium carbonate;
(1E,4E)-1,5-diphenylpenta-1,4-dien-3-one palladium(II) complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; 1,4-dioxane; diphenylether;
