N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Base Information

Chemical Name:N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide
CAS No.:1616929-89-5
Molecular Formula:C₂₀H₁₄F₂N₄OS
Molecular Weight:396.42
Hs Code.:

Synonyms:N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Suppliers and Price of N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

There total 4 articles about N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1616930-44-9
C₁₆H₁₅N₃O₂S

: 5509-65-9
2,6-difluoroaniline

: 1616929-89-5
N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: With trimethylaluminum; In n-heptane; toluene; at 100 ℃; for 2h;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1616929-89-5
N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; sodium / diethyl ether / 0.25 h / 20 °C

2: hydrogenchloride / water; ethanol / 0.5 h / 20 °C

3: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 2 h / 120 °C / Inert atmosphere

4: trimethylaluminum / n-heptane; toluene / 2 h / 100 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; trimethylaluminum; sodium; sodium carbonate; In tetrahydrofuran; diethyl ether; ethanol; n-heptane; water; toluene; 3: |Negishi Coupling;

Reference yield:

: 473537-92-7
ethyl 4-(3-bromophenyl)-2,4-dioxobutanoate

: 1616929-89-5
N-(2,6-difluoro-phenyl)-1-methyl-5-(3-thiazol-2-yl-phenyl)-1H-pyrazole-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; ethanol / 0.5 h / 20 °C

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 2 h / 120 °C / Inert atmosphere

3: trimethylaluminum / n-heptane; toluene / 2 h / 100 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trimethylaluminum; sodium carbonate; In tetrahydrofuran; ethanol; n-heptane; water; toluene; 2: |Negishi Coupling;