2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile

Base Information

Chemical Name:2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile
CAS No.:86309-98-0
Molecular Formula:C₂₂H₃₁NO
Molecular Weight:325.494
Hs Code.:

Synonyms:2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile

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Chemical Property of 2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile

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Technology Process of 2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile

There total 1 articles about 2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3917-41-7
(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal

: 765-76-4
2-Methyl-1-cyclopenten-1-carbonitril

: 86309-98-0
2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF,-78 deg C -> 25 deg C, 40 min, 2.) 0 deg c, 3.) -78 deg C, 1 h; -78 deg C -> 0 deg C, 40 min;
DOI:10.1021/ja00353a068

Reference yield:

: 86309-98-0
2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile

: 86309-95-7
2-[(1E,3E,5E)-4-Methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-cyclopent-1-enecarbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Ac₂O, pyridine, 2.) t-BuOK / 1.) 25 deg C, 2 h, 2.) THF, 0 deg C, 30 min

2: 60 percent / aq. (COOH)2 / ethyl acetate / -40 deg C, 15 min, -40 deg C -> 25 deg C

With pyridine; potassium tert-butylate; oxalic acid; acetic anhydride; In ethyl acetate;
DOI:10.1021/ja00353a068

Reference yield:

: 86309-98-0
2-[(3E,5E)-2-Hydroxy-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-3,5-dienyl]-cyclopent-1-enecarbonitrile

: 86309-99-1
2-[(1E,3E,5E)-4-Methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-cyclopent-1-enecarbonitrile

Guidance literature:: With pyridine; potassium tert-butylate; acetic anhydride; Yield given. Multistep reaction; 1.) 25 deg C, 2 h, 2.) THF, 0 deg C, 30 min;
DOI:10.1021/ja00353a068