methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate

Base Information

• Chemical Name: methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate
• CAS No.: 218898-44-3
• Molecular Formula: C₁₄H₂₀O₆S
• Molecular Weight: 316.375
• Mol file: 218898-44-3.mol

Synonyms:methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate

Chemical Property of methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate

There total 3 articles about methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 2,2-dimethoxy-4-phenylsulfanylpentanoate (556051-18-4) → methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate (218898-44-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 3h;

DOI:10.1021/jo034018e

Reference yield:

methyl (E)-2-oxo-3-pentenoate (55674-15-2) → methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate (218898-44-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 8.64 g / p-TSA / methanol / 72 h / Heating

3: 94 percent / m-CPBA / CH₂Cl₂ / 3 h / 0 °C

With toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1021/jo034018e

Reference yield:

2-oxo-4-phenylsulfanyl-pentanoic acid methyl ester (556051-17-3) → methyl 4-benzenesulfonyl-2,2-dimethoxypentanoate (218898-44-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 8.64 g / p-TSA / methanol / 72 h / Heating

2: 94 percent / m-CPBA / CH₂Cl₂ / 3 h / 0 °C

With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1021/jo034018e

upstream raw materials:

methyl 2,2-dimethoxy-4-phenylsulfanylpentanoate

methyl (E)-2-oxo-3-pentenoate

2-oxo-4-phenylsulfanyl-pentanoic acid methyl ester

Downstream raw materials:

5-Benzenesulfonyl-3,3-dimethoxy-5-methyl-6-phenethyl-tetrahydro-pyran-2-one

(2R,3S,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-7-trimethylsilanyl-hept-6-yn-1-ol

(Z)-1-(ethylamino)-4,4-dimethoxy-6-(phenylsulfonyl)hept-1-en-3-one

3,3-dimethoxy-5-methyl-6-(5-oxohexyl)-5-(phenylsulfonyl)tetrahydro-2H-pyran-2-one