N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine

Base Information

• Chemical Name: N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine
• CAS No.: 114743-31-6
• Molecular Formula: C₅₂H₄₉N₅O₇
• Molecular Weight: 855.99

Synonyms:N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine

Chemical Property of N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine

Chemical Property:

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Technology Process of N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine

There total 13 articles about N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N6,O5'-bis(4,4'-dimethoxytrityl)-2',3'-di-O-mesyladenosine (124040-42-2) → N6,O5'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine (114743-31-6)

Guidance literature:

With potassium hydroxide; sodium tetrahydroborate; In methanol; benzene; for 24h; Ambient temperature;

DOI:10.1016/0008-6215(89)84088-1

Reference yield: 95.0%

N6,O5'-bis-(4,4'-dimethoxytrityl)-3'-O-tosyladenosine (109923-59-3) → N6,O5'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine (114743-31-6)

Guidance literature:

With sodium tetrahydroborate; magnesium methanolate; In methanol; benzene; at 65 ℃; for 0.116667h;

DOI:10.1016/S0040-4039(01)83865-X

Reference yield: 87.0%

N6,O5'-bis(4,4'-dimethoxytrityl)-3'-O-mesyl-2'-O-tosyladenosine (114765-61-6) → N6,O5'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-β-D-threo-pentofuranosyl)adenine (114743-31-6)

Guidance literature:

With potassium hydroxide; sodium tetrahydroborate; In methanol; benzene; for 24h; Ambient temperature;

DOI:10.1016/0008-6215(89)84088-1

upstream raw materials:

N⁶,O^5'-bis-(4,4'-dimethoxytrityl)-3'-O-tosyladenosine

N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-3'-O-mesyl-2'-O-tosyladenosine

2,2-Dimethyl-propionic acid (2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-4-methanesulfonyloxy-tetrahydro-furan-3-yl ester

N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-2',3'-di-O-mesyladenosine

Downstream raw materials:

N⁶,O^5'-bis(4,4'-dimethoxytrityl)-9-<(2R)-2-azido-2,3-dideoxy-β-D-glycero-pentofuranosyl>adenine

N⁶,O^5'-bis(4,4'-dimethoxytrityl)-9-(3-deoxy-2-O-mesyl-β-D-threo-pentofuranosyl)adenine

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