2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine

Base Information

Chemical Name:2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine
CAS No.:1325188-83-7
Molecular Formula:C₁₆H₂₅N₃O₃S
Molecular Weight:339.459
Hs Code.:

Synonyms:2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine

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Chemical Property of 2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine

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Technology Process of 2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine

There total 3 articles about 2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 874959-39-4
3-(cis-3,5-dimethyl-1-piperazinyl)-4-(methyloxy)aniline

: 1633-82-5
3-chloro-n-propanesulfonyl chloride

: 1325188-83-7
2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine

Guidance literature:: 3-(cis-3,5-dimethyl-1-piperazinyl)-4-(methyloxy)aniline; 3-chloro-n-propanesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 4h;

Reference yield:

: 1325190-19-9
C₁₆H₂₆ClN₃O₃S

: 1325188-83-7
2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 874959-39-4
3-(cis-3,5-dimethyl-1-piperazinyl)-4-(methyloxy)aniline

: 1325188-83-7
2-(3-((3S,5R)-3,5-dimethylpiperazin-1-yl)-4-methoxyphenyl)-1,1-dioxoisothiazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 4 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;