(R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate

Base Information

Chemical Name:(R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate
CAS No.:1392409-11-8
Molecular Formula:C₃₈H₅₁IO₄Si
Molecular Weight:726.811
Hs Code.:

Synonyms:(R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate

Chemical Property:

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Technology Process of (R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate

There total 11 articles about (R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₈Cl₃IO₄Si

: 104784-02-3
(R)-1-<(triphenylmethyl)oxy>pentan-4-ol

: 1392409-11-8
(R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃; for 22h;
DOI:10.1021/ol3018566

Reference yield:

: 1392409-02-7
(R)-3-hydroxypent-4-ynoic acid

: 1392409-11-8
(R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-dimethylpyridine / dichloromethane / -40 - -20 °C

2.1: Schwartz's reagent / dichloromethane / 1 h

2.2: 7 h / 0 °C

3.1: potassium carbonate / tetrahydrofuran; methanol; water / 24 h

4.1: triethylamine / tetrahydrofuran / 23 h

5.1: dmap / tetrahydrofuran / 22 h / 20 °C

With 2,6-dimethylpyridine; dmap; Schwartz's reagent; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; 4.1: Yamaguchi esterification;
DOI:10.1021/ol3018566

Reference yield:

: 174500-52-8
(R)-1-(trityloxy)pentan-4-yl acetate

: 1392409-11-8
(R)-5-(trityloxy)pentan-2-yl (R,E)-5-iodo-3-(triisopropylsilyloxy)pent-4-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 5 h / 20 °C

2: dmap / tetrahydrofuran / 22 h / 20 °C

With dmap; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/ol3018566