1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose

Base Information

• Chemical Name: 1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose
• CAS No.: 63700-25-4
• Molecular Formula: C₁₅H₁₄ClF₃N₂O₆
• Molecular Weight: 410.734
• Mol file: 63700-25-4.mol

Synonyms:1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose

Chemical Property of 1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose

There total 2 articles about 1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-Nitro-benzoic acid (2S,3S,4S,6R)-6-chloro-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester (59044-90-5,62414-05-5,63700-25-4,67463-63-2,70629-82-2,78548-38-6,81844-79-3,128572-89-4)

Guidance literature:

HCl, 1,4-Di-O-p-nitrobenzoyl-3-N-trifluoracetyldaunosamin, p-Nitrobenzoesaeure;

DOI:10.1021/jm00201a009

Reference yield:

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose (52583-22-9) → 1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose (63700-25-4)

Guidance literature:

DOI:10.1016/S0040-4020(01)86162-7

Reference yield: 53.0%

(S)-cis-1,2,3,4,6,11-hexahydro-1,3,5,12-tetrahydroxy-3-methylnaphthacene-6,11-quinone (78548-50-2) + 1-chloro-2,3,6-trideoxy-4-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxohexopyranose (63700-25-4) → 4-Nitro-benzoic acid (2S,3S,4S,6R)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-6-((1S,3S)-3,5,12-trihydroxy-3-methyl-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-tetrahydro-pyran-3-yl ester (78499-71-5,81844-80-6)

Guidance literature:

With silver trifluoromethanesulfonate; In tetrahydrofuran; diethyl ether; at -5 ℃; for 3.5h;

DOI:10.1021/jm00171a010

upstream raw materials:

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose

Downstream raw materials:

(-)-4'-O-p-Nitrobenzoyl-N-trifluoroacetyl-4-demethoxydaunorubicin

4-Nitro-benzoic acid (2S,3S,4S,6R)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-6-((1S,3S)-3,5,12-trihydroxy-3-methyl-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-tetrahydro-pyran-3-yl ester

4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3S)-3-ethyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((1S,3S)-3-acetoxymethyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester