5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

Base Information

Chemical Name:5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione
CAS No.:97322-94-6
Molecular Formula:C₂₅H₂₉NO₅S
Molecular Weight:455.575
Hs Code.:

Synonyms:5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

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Chemical Property of 5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

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Technology Process of 5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

There total 10 articles about 5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-chloro-3-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]phenyl}propionate

: 97322-94-6
5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

Guidance literature:: With thiourea; In sulfolane; ethyl acetate;

Reference yield:

: 109-86-4,95507-80-5
2-methoxy-ethanol

: ethyl 3-{4-[2-(6-acetoxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]phenyl}-2-chloropropionate

: 97322-94-6
5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; thiourea; In sulfolane; water; ethyl acetate; benzene;

Reference yield:

: 79907-48-5
2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-benzo[1,2-b]pyran-2-yl)ethanol

: 97322-94-6
5-{4-[2-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF

2: 1.) NaH / 1.) DMSO, benzene

3: AcOH, 10percent H₂SO₄

4: pyridine

5: H₂ / 10percent Pd-C / methanol; benzene

6: 1.) aq. NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone

7: 2.) AcOH, conc. HCl / 1.) sulfolane, 2.) H₂O

With pyridine; copper(I) oxide; hydrogenchloride; sulfuric acid; hydrogen; sodium hydride; acetic acid; sodium nitrite; palladium on activated charcoal; In methanol; benzene;
DOI:10.1021/jm00122a022