5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one

Base Information

• Chemical Name: 5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one
• CAS No.: 1150615-73-8
• Molecular Formula: C₁₄H₁₃N₃O₃S
• Molecular Weight: 303.342
• Mol file: 1150615-73-8.mol

Synonyms:5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one

Chemical Property of 5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one

Chemical Property:

Purity/Quality:

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Technology Process of 5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one

There total 1 articles about 5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

S-methylisothiourea hemisulphate (147895-43-0) + 3,4-dimethoxy-benzaldehyde (120-14-9) + ethyl 2-cyanoacetate (105-56-6) → 5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one (1150615-73-8)

Guidance literature:

With potassium carbonate; In ethanol; at 80 ℃; for 5h;

DOI:10.1016/j.ejmech.2015.06.024

Reference yield: 91.0%

5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one (1150615-73-8) → 5-cyano-6-chloro-2-(methylthio)-4-(3,4-dimethoxyphenyl)pyrimidine

Guidance literature:

With trichlorophosphate; at 105 ℃; for 3h;

DOI:10.1016/j.ejmech.2015.06.024

Reference yield:

5-cyano-2-methylthio-4-(3,4-dimethoxyphenyl)pyrimidin-6(1H)-one (1150615-73-8) → C13H12N4O3 (1150615-69-2)

Guidance literature:

With ammonium acetate; at 210 ℃; for 2h;

DOI:10.1080/10426500801967963

upstream raw materials:

S-methylisothiourea hemisulphate

3,4-dimethoxy-benzaldehyde

ethyl 2-cyanoacetate

Downstream raw materials:

C₁₃H₁₂N₄O₃

C₁₃H₁₃N₅O₃