1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one

Base Information

Chemical Name:1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one
CAS No.:1369968-52-4
Molecular Formula:C₆₀H₇₆N₁₀O₄
Molecular Weight:1001.33
Hs Code.:

Synonyms:1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one

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Chemical Property of 1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one

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Technology Process of 1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one

There total 4 articles about 1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1369968-51-3
1,1'-(1,1'-(4-iodopyridine-2,6-diyl)bis(1H-pyrazole-4,1-diyl))-dioctan-1-one

: 4612-26-4
1,4-Phenyldiboronic acid

: 1369968-52-4
1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; at 80 ℃; for 72h; Inert atmosphere;
DOI:10.1021/jo300050m

Reference yield:

: 629-05-0
n-octyne

: 1369968-52-4
1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine / 1,4-dioxane / 48 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 1 h

2.2: 1 h

3.1: oxalyl dichloride / tetrahydrofuran; dichloromethane / 4 h / 20 °C

4.1: sodium azide / water; acetone

5.1: benzene / 16 h / Reflux

6.1: potassium carbonate / methanol / 8 h

6.2: 2 h / Cooling with ice

7.1: iodine; potassium iodide; isopentyl nitrite / dichloromethane / 12 h / Inert atmosphere; Heating

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 72 h / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; oxalyl dichloride; iodine; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; potassium iodide; lithium hydroxide; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone; benzene; 1.1: Sonogashira coupling / 5.1: Curtius rearrangement / 8.1: Suzuki coupling;
DOI:10.1021/jo300050m

Reference yield:

: 1369968-49-9
2,6-bis(4-(oct-1-ynyl)-1H-pyrazol-1-yl)isonicotinic acid

: 1369968-52-4
1,1',1'',1'''-(1,1',1'',1'''-(4,4'-(1,4-phenylene)bis(pyridine-6,4,2-triyl))tetrakis(1H-pyrazole-4,1-diyl))tetraoctan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: oxalyl dichloride / tetrahydrofuran; dichloromethane / 4 h / 20 °C

2.1: sodium azide / water; acetone

3.1: benzene / 16 h / Reflux

4.1: potassium carbonate / methanol / 8 h

4.2: 2 h / Cooling with ice

5.1: iodine; potassium iodide; isopentyl nitrite / dichloromethane / 12 h / Inert atmosphere; Heating

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane / 72 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; oxalyl dichloride; iodine; sodium carbonate; potassium carbonate; potassium iodide; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone; benzene; 3.1: Curtius rearrangement / 6.1: Suzuki coupling;
DOI:10.1021/jo300050m