2H-Indole-2-carboxylicacid,3,5-dihydro-6-hydroxy-5-oxo-,methylester(7CI,9CI)

Base Information

• Chemical Name: 2H-Indole-2-carboxylicacid,3,5-dihydro-6-hydroxy-5-oxo-,methylester(7CI,9CI)
• CAS No.: 90924-67-7
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.186
• Mol file: 90924-67-7.mol

Synonyms:2H-Indole-2-carboxylicacid,3,5-dihydro-6-hydroxy-5-oxo-,methylester(7CI,9CI)

Chemical Property of 2H-Indole-2-carboxylicacid,3,5-dihydro-6-hydroxy-5-oxo-,methylester(7CI,9CI)

Chemical Property:

• PSA: 75.96000
• LogP: -0.24070

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Indole-2-carboxylicacid,3,5-dihydro-6-hydroxy-5-oxo-,methylester(7CI,9CI)

There total 3 articles about 2H-Indole-2-carboxylicacid,3,5-dihydro-6-hydroxy-5-oxo-,methylester(7CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-3-(3,4-dihydroxyphenyl)alanine methyl ester hydrochloride (40611-00-5) → DL-dopachrome methyl ester (90924-67-7,195058-98-1,195059-10-0)

Guidance literature:

With potassium hexacyanoferrate(III); In water; for 0.0666667h; 0.5 M phosphate buffer, pH=6.5;

DOI:10.1016/S0040-4020(01)87714-0

Reference yield:

(+/-)-3-(3,4-dihydroxyphenyl)-2-methyl-DL-alanine (7101-51-1,41439-83-2,71855-43-1) → DL-dopachrome methyl ester (90924-67-7,195058-98-1,195059-10-0)

Guidance literature:

With sodium periodate; In phosphate buffer; for 0.166667h; pH=6.0;

DOI:10.1016/s0960-894x(99)00561-2

Reference yield:

dopa (63-84-3,90638-38-3) → DL-dopachrome methyl ester (90924-67-7,195058-98-1,195059-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl

2: potassium ferricyanide / H₂O / 0.07 h / 0.5 M phosphate buffer, pH=6.5

With hydrogenchloride; potassium hexacyanoferrate(III); In water;

DOI:10.1016/S0040-4020(01)87714-0

upstream raw materials:

DL-3-(3,4-dihydroxyphenyl)alanine methyl ester hydrochloride

(+/-)-3-(3,4-dihydroxyphenyl)-2-methyl-DL-alanine

dopa