4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide

Base Information

• Chemical Name: 4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide
• CAS No.: 857546-99-7
• Molecular Formula: C₂₁H₁₈N₄O₃S
• Molecular Weight: 406.465
• Mol file: 857546-99-7.mol

Synonyms:4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide

Chemical Property of 4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide

There total 4 articles about 4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid hydrazide (959336-88-0) → 4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide (857546-99-7)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite;

DOI:10.1021/ja01228a064

Reference yield:

4-amino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid ethyl ester (716377-26-3) → 4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide (857546-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: chloroform

2: ethanol; hydrazine hydrate

3: acetic acid; aqueous hydrochloric acid; aqueous sodium nitrite solution

With hydrogenchloride; ethanol; chloroform; hydrazine hydrate; acetic acid; sodium nitrite;

DOI:10.1021/ja01228a064

Reference yield:

4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid ethyl ester (959356-07-1) → 4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid-azide (857546-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; hydrazine hydrate

2: acetic acid; aqueous hydrochloric acid; aqueous sodium nitrite solution

With hydrogenchloride; ethanol; hydrazine hydrate; acetic acid; sodium nitrite;

DOI:10.1021/ja01228a064

upstream raw materials:

4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid hydrazide

4-amino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid ethyl ester

4-benzoylamino-5-(3-phenoxy-propyl)-thiophene-3-carboxylic acid ethyl ester

benzoyl chloride

Downstream raw materials:

N-[4-isocyanato-2-(3-phenoxy-propyl)-[3]thienyl]-benzamide

[4-benzoylamino-5-(3-phenoxy-propyl)-[3]thienyl]-carbamic acid ethyl ester