benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate

Base Information

Chemical Name:benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate
CAS No.:1431473-03-8
Molecular Formula:C₂₁H₂₂N₂O₆
Molecular Weight:398.415
Hs Code.:

Synonyms:benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate

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Chemical Property of benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate

There total 9 articles about benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431473-24-3
(2R,5S)-benzyl 5-hydroxy-2-methylpiperidine-1-carboxylate

: 62-23-7
4-nitro-benzoic acid

: 1431473-03-8
benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate

Guidance literature:: With diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine; In tetrahydrofuran; at -25 - 20 ℃; Inert atmosphere;

Reference yield:

: (±)-benzyl trans-5-hydroxy-2-methylpiperidine-1-carboxylate

: 1431473-03-8
benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.33 h / -78 °C

1.2: -78 - 20 °C

2.1: lithium borohydride / methanol; tetrahydrofuran / 0.5 h / -10 - -5 °C

3.1: methanol / Supercritical conditions

4.1: diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine / tetrahydrofuran / -25 - 20 °C / Inert atmosphere

With lithium borohydride; oxalyl dichloride; dimethyl sulfoxide; diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 1.1: |Swern Oxidation / 1.2: |Swern Oxidation;

Reference yield:

: 1314395-91-9
(±)-benzyl 2-methyl-5-oxopiperidine-1-carboxylate

: 1431473-03-8
benzyl (2R,5R)-2-methyl-5-{[(4-nitrophenyl)carbonyl]oxy}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / methanol; tetrahydrofuran / 0.5 h / -10 - -5 °C

2: methanol / Supercritical conditions

3: diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine / tetrahydrofuran / -25 - 20 °C / Inert atmosphere

With lithium borohydride; diethylazodicarboxylate; 4-(N,N-Dimethylamino)triphenylphosphine; In tetrahydrofuran; methanol;