1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester
CAS No.:790305-01-0
Molecular Formula:C₃₃H₅₇N₃O₇Si
Molecular Weight:635.917
Hs Code.:

1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

Synonyms:1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

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Chemical Property of 1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

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Technology Process of 1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

There total 1 articles about 1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 790305-01-0
1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine; HATU / dichloromethane / 72 h / 20 °C

2: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

3: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 48 h / 20 °C

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; water; HATU; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 790305-01-0
1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

: 1029259-57-1
C₃₂H₄₄N₄O₈S

Guidance literature:: Multi-step reaction with 6 steps

1.1: tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride / dichloromethane / 0.25 h / Heating / reflux

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

2.2: pH 4

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating / reflux

3.2: 4 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

5.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C

6.1: MgBr₂*Et₂O / tetrahydrofuran / 3 h / 0 °C / Cooling with acetone-dry ice

With lithium hydroxide; MgBr₂*Et₂O; tetrabutyl ammonium fluoride; water; Dess-Martin periodane; 1,1'-carbonyldiimidazole; tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 790305-01-0
1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

: 1029259-59-3
C₃₈H₄₈N₄O₈S

Guidance literature:: Multi-step reaction with 6 steps

1.1: tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride / dichloromethane / 0.25 h / Heating / reflux

2.1: lithium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

2.2: pH 4

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Heating / reflux

3.2: 4 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

5.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C

6.1: MgBr₂*Et₂O / tetrahydrofuran / 0 - 20 °C

6.2: 3 h / -78 - 0 °C

With lithium hydroxide; MgBr₂*Et₂O; tetrabutyl ammonium fluoride; water; Dess-Martin periodane; 1,1'-carbonyldiimidazole; tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; In tetrahydrofuran; methanol; dichloromethane;