4-Methyl-6-(pyridin-3-YL)pyrimidin-2-amine

Base Information

• Chemical Name: 4-Methyl-6-(pyridin-3-YL)pyrimidin-2-amine
• CAS No.: 90916-52-2
• Molecular Formula: C10H10 N4
• Molecular Weight: 186.216
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10591712
• Nikkaji Number: J2.209.457B
• Wikidata: Q82485559
• Mol file: 90916-52-2.mol

Synonyms:90916-52-2;4-METHYL-6-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;4-Methyl-6-pyridin-3-ylpyrimidin-2-amine;3-AMINO-4-METHYL-6-(PYRIDIN-3-YL)-PYRIMIDINE;2-Amino-4-methyl-6-(3-pyridyl)pyrimidine;2-Pyrimidinamine, 4-methyl-6-(3-pyridinyl)-;SCHEMBL3951935;DTXSID10591712;MFCD08705820;AKOS011770001;SB53061;TS-02606;DB-078835;CS-0367339;Z991536940

Chemical Property of 4-Methyl-6-(pyridin-3-YL)pyrimidin-2-amine

Chemical Property:

• PSA: 64.69000
• LogP: 2.01040
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 186.090546336
• Heavy Atom Count: 14
• Complexity: 185

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-6-pyridin-3-ylpyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)N)C2=CN=CC=C2

Technology Process of 4-Methyl-6-(pyridin-3-YL)pyrimidin-2-amine

There total 2 articles about 4-Methyl-6-(pyridin-3-YL)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-amino-6-methyl-4-chloropyrimidine (5600-21-5) + 3-pyridylboronic acid (1692-25-7) → 4-methyl-6-(pyridin-3-yl)pyrimidin-2-amine (90916-52-2)

Guidance literature:

With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 78 ℃; for 7h;

DOI:10.3390/molecules13040818

Reference yield:

→ 4-methyl-6-(pyridin-3-yl)pyrimidin-2-amine (90916-52-2)

Guidance literature:

Nicotinoylaceton u. Guanidincarbonat (170grad);

Reference yield: 68.0%

3,6-bis(trifluoromethyl)bromobenzene (328-70-1) + 4-methyl-6-(pyridin-3-yl)pyrimidin-2-amine (90916-52-2) → N-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-6-(pyridin-3-yl)pyrimidin-2-amine (1234327-44-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; for 8h; Inert atmosphere; Reflux;

DOI:10.1016/j.bmc.2010.04.037

upstream raw materials:

2-amino-6-methyl-4-chloropyrimidine

3-pyridylboronic acid

Downstream raw materials:

4-methyl-N-(2,4-dimethylphenyl)-6-(pyridin-3-yl)pyrimidin-2-amine

N-(2,4-dimethylbenzyl)-4-methyl-6-(pyridin-3-yl)pyrimidin-2-amine

tetrakis(μ-2-fluorobenzoato-O,O')-bis(3-(2-amino-4-methylpyrimidin-6-yl)pyridine)-dicopper(II)

N-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-6-(pyridin-3-yl)pyrimidin-2-amine