(6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid

Base Information

Chemical Name:(6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid
CAS No.:121194-90-9
Molecular Formula:C₂₅H₂₉NO₇
Molecular Weight:455.508
Hs Code.:

Synonyms:(6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid

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Chemical Property of (6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid

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Technology Process of (6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid

There total 6 articles about (6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 121194-89-6
(6R,7R,8S,8aR,2'R,4'S,5'R)-(+)-4'-(t-butyldimethylsiloxymethyl)-2'-phenyl-1',3'-dioxan-5'-yl 6,7-bis-(3,4-dimethoxyphenyl)-5-oxoindolizidine-8-carboxylate

: 121194-90-9
(6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 24h; Heating;

Reference yield:

: 52840-52-5,24316-12-9
(E)-2,3-bis(3,4-dimethoxyphenyl)acrylic acid

: 121194-90-9
(6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl dichloride / CH₂Cl₂ / 4 h / Ambient temperature

2: 100 percent / aq. NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

3: 100 percent / aq. HOAc / 3.5 h / 60 °C

4: 85 percent / acetonitrile / 24 h / Ambient temperature

5: 76 percent / t-butyldimethylsilyl trifluoromethanesulphonate, NEt₃ / CH₂Cl₂ / 2 h / -78 - 5 °C

6: 99 percent / KOH / ethanol / 24 h / Heating

With potassium hydroxide; oxalyl dichloride; t-butyldimethylsiyl triflate; sodium hydrogencarbonate; acetic acid; triethylamine; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: (E)-2,3-bis(3,4-dimethoxyphenyl)acryloyl chloride

: 121194-90-9
(6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / aq. NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

2: 100 percent / aq. HOAc / 3.5 h / 60 °C

3: 85 percent / acetonitrile / 24 h / Ambient temperature

4: 76 percent / t-butyldimethylsilyl trifluoromethanesulphonate, NEt₃ / CH₂Cl₂ / 2 h / -78 - 5 °C

5: 99 percent / KOH / ethanol / 24 h / Heating

With potassium hydroxide; t-butyldimethylsiyl triflate; sodium hydrogencarbonate; acetic acid; triethylamine; In ethanol; dichloromethane; acetonitrile;