Technology Process of 3-cyclohexyl-2-(4-(cyclopentylsulfonyl)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(thiazol-2-yl)propanamide
There total 9 articles about 3-cyclohexyl-2-(4-(cyclopentylsulfonyl)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(thiazol-2-yl)propanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium hydroxide / Reflux
2: sulfuric acid / Reflux
3: trichlorophosphate; N,N-dimethyl-aniline; tetraethylammonium chloride / acetonitrile / 80 °C
4: sodium hydride / dimethyl sulfoxide / 80 °C
5: 3-chloro-benzenecarboperoxoic acid / dichloromethane
6: lithium hydroxide / 1,4-dioxane
7: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
With
sulfuric acid; tetraethylammonium chloride; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N,N-dimethyl-aniline; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; lithium hydroxide; trichlorophosphate;
In
1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2013.01.093
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium hydroxide / Reflux
2: sulfuric acid / Reflux
3: trichlorophosphate; N,N-dimethyl-aniline; tetraethylammonium chloride / acetonitrile / 80 °C
4: sodium hydride / dimethyl sulfoxide / 80 °C
5: 3-chloro-benzenecarboperoxoic acid / dichloromethane
6: lithium hydroxide / 1,4-dioxane
7: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
With
sulfuric acid; tetraethylammonium chloride; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N,N-dimethyl-aniline; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; lithium hydroxide; trichlorophosphate;
In
1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2013.01.093
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trichlorophosphate; N,N-dimethyl-aniline; tetraethylammonium chloride / acetonitrile / 80 °C
2: sodium hydride / dimethyl sulfoxide / 80 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane
4: lithium hydroxide / 1,4-dioxane
5: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide
With
tetraethylammonium chloride; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N,N-dimethyl-aniline; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; trichlorophosphate;
In
1,4-dioxane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2013.01.093
