N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide

Base Information

Chemical Name:N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide
CAS No.:1221446-10-1
Molecular Formula:C₃₁H₄₂ClN₃O₃S
Molecular Weight:572.212
Hs Code.:

Synonyms:N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide

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Chemical Property of N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide

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Technology Process of N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide

There total 8 articles about N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1221446-22-5
N-(3-chloro-4-methylphenyl)-N-(3-chloropropyl)cyclohexylcarboxamide

: 1221446-24-7
N-(3-exo-8-azabicyclo[3.2.1]oct-3-yl)-4-toluenesulfonamide

: 1221446-10-1
N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 6h; Reflux;

Reference yield:

: 76272-34-9
8-benzyl-8-azabicyclo[3.2.1] octan-3-one oxime

: 1221446-10-1
N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium; pentan-1-ol / 2 h / Reflux

2: triethylamine / dichloromethane / 6 h / 20 °C

3: ammonium formate / palladium 10% on activated carbon / methanol / 12 h / Reflux

4: potassium carbonate / potassium iodide / acetonitrile / 6 h / Reflux

With pentan-1-ol; ammonium formate; sodium; potassium carbonate; triethylamine; palladium 10% on activated carbon; potassium iodide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 1221446-10-1
N-(3-chloro-4-methylphenyl)-N-(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)cyclohexylcarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; water / 1 h / Reflux

1.2: 6 h / 0 - 50 °C

1.3: pH 12

2.1: hydroxylamine hydrochloride; pyridine / ethanol / 18 h / Reflux

3.1: sodium; pentan-1-ol / 2 h / Reflux

4.1: triethylamine / dichloromethane / 6 h / 20 °C

5.1: ammonium formate / palladium 10% on activated carbon / methanol / 12 h / Reflux

6.1: potassium carbonate / potassium iodide / acetonitrile / 6 h / Reflux

With pyridine; hydrogenchloride; pentan-1-ol; hydroxylamine hydrochloride; water; ammonium formate; sodium; potassium carbonate; triethylamine; palladium 10% on activated carbon; potassium iodide; In methanol; ethanol; dichloromethane; acetonitrile;