tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate

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Chemical Name:tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate
CAS No.:174488-24-5
Molecular Formula:C₄₀H₄₉N₉O₇
Molecular Weight:767.885
Hs Code.:

tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate

Synonyms:tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate

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Chemical Property of tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate

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Technology Process of tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate

There total 11 articles about tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 174487-71-9
4-{N-[(6R/6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid

: 174488-23-4
tert-butyl (4R)-4-[N-(α-tert-butyl-L-γ-glutamyl)amino]-4-(5-tetrazolyl)butyrate

: 174488-24-5
tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;
DOI:10.1021/jm991119p

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 174488-24-5
tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate

Guidance literature:: Multi-step reaction with 4 steps

1: NMM / tetrahydrofuran / 0.17 h / -20 °C

2: tetrahydrofuran / 4.75 h / -20 - 20 °C

3: H₂ / 10percent Pd/C / ethanol / 22 h / 20 °C

4: 55 percent / PyBOP; DIEA / dimethylformamide / 2.5 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; 10percent Pd/C; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p

Reference yield:

: 51644-83-8
N-(benzyloxy)carbonyl-D-glutamic acid 5-tert-butyl ester

: 174488-24-5
tert-butyl (4R)-4-{N-{N-{4-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-α-tert-butyl-L-γ-glutamyl}amino}-4-(5-tetrazolyl)butyrate

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / tetrahydrofuran / 0.17 h / -15 °C

2: NH₃ / tetrahydrofuran / 0.5 h / -5 - 5 °C

3: 86 percent / POCl₃; pyridine / CH₂Cl₂ / 15 h / 20 °C

4: 84 percent / NaN₃; NH₄Cl / dimethylformamide / 20 h / 90 - 95 °C

5: 91 percent / H₂ / 10percent Pd/C / ethanol / 16 h / 20 °C

6: tetrahydrofuran / 4.75 h / -20 - 20 °C

7: H₂ / 10percent Pd/C / ethanol / 22 h / 20 °C

8: 55 percent / PyBOP; DIEA / dimethylformamide / 2.5 h / 20 °C

With pyridine; sodium azide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; hydrogen; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm991119p