1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane

Base Information

Chemical Name:1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane
CAS No.:132777-41-4
Molecular Formula:C₂₄H₃₈O₅Si
Molecular Weight:434.648
Hs Code.:

Synonyms:1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane

Suppliers and Price of 1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane

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Chemical Property of 1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane

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Technology Process of 1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane

There total 7 articles about 1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 85757-86-4
(furan-3-ylmethyl)magnesium chloride

: 132777-20-9
1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-<<(methoxyethoxy)methyl>oxy>-3-<<(4-methylphenyl)sulfonyl>oxy>propane

: 132777-41-4
1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane

Guidance literature:: With dilithium tetrachlorocuprate; In tetrahydrofuran; at 0 ℃; for 6h;
DOI:10.1021/jo00008a049

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 132777-41-4
1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-BuLi / 1) THF, -76 deg C, 10 min, 2) THF, 1 h

2: 90 percent / diisopropylethyl amine / CH₂Cl₂ / 3.5 h / 23 °C

3: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

4: 97 percent / pyridine / a) 0 deg C, 15 min, b) 20 min

5: 99 percent / Li₂CuCl₄ / tetrahydrofuran / 6 h / 0 °C

With pyridine; lithium aluminium tetrahydride; n-butyllithium; dilithium tetrachlorocuprate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00008a049

Reference yield:

: 132777-16-3
tert-butyl 3-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-3-hydroxypropanoate

: 132777-41-4
1-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-furan-3-yl-1-<<(methoxyethoxy)methyl>oxy>butane

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / diisopropylethyl amine / CH₂Cl₂ / 3.5 h / 23 °C

2: 92 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

3: 97 percent / pyridine / a) 0 deg C, 15 min, b) 20 min

4: 99 percent / Li₂CuCl₄ / tetrahydrofuran / 6 h / 0 °C

With pyridine; lithium aluminium tetrahydride; dilithium tetrachlorocuprate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00008a049