Technology Process of <1R-(1α,3α,4β,5α)>-1,3,4-trihydroxy-5-<(diisopropoxyphosphinyl)methyl>cyclohexan-1-carboxylic acid
There total 12 articles about <1R-(1α,3α,4β,5α)>-1,3,4-trihydroxy-5-<(diisopropoxyphosphinyl)methyl>cyclohexan-1-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxygen; sodium hydrogencarbonate;
platinum;
In
water;
at 55 ℃;
for 8h;
DOI:10.1021/ja00038a002
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) n-butyllithium, 2.) boron trifluoride etherate
2: 93 percent / 50percent aq. acetic acid / tetrahydrofuran / 5 h / 65 - 75 °C
3: 100 percent / H2 / 10percent Pd/C / methanol / 2 h / 2585.7 Torr
4: 65 percent / O2, NaHCO3 / Pt / H2O / 8 h / 55 °C
With
n-butyllithium; boron trifluoride diethyl etherate; hydrogen; oxygen; sodium hydrogencarbonate; acetic acid;
palladium on activated charcoal; platinum;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/ja00038a002
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 85 percent / p-toluenesulfonic acid (p-TsOH) / benzene / Heating
2: 75 percent / NaBH4 / ethanol / 0.75 h / 0 °C
3: 70 percent / p-toluenesulfonic acid (p-TsOH) / dimethylformamide / 24 h / Ambient temperature
4: 79 percent / N-bromosuccinimide (NBS) / benzene / Heating
5: 11 percent / MeONa / tetrahydrofuran; methanol / 0.5 h / Heating
6: 1.) NaH / 1.) THF, hexane, 30 min, 2.) THF, hexane, RT, 12 h
7: 1.) n-butyllithium, 2.) boron trifluoride etherate
8: 93 percent / 50percent aq. acetic acid / tetrahydrofuran / 5 h / 65 - 75 °C
9: 100 percent / H2 / 10percent Pd/C / methanol / 2 h / 2585.7 Torr
10: 65 percent / O2, NaHCO3 / Pt / H2O / 8 h / 55 °C
With
sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; boron trifluoride diethyl etherate; hydrogen; oxygen; sodium methylate; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid;
palladium on activated charcoal; platinum;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00038a002
