(+/-)-(1'S',2'S,3'R)-7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid

Base Information

Chemical Name:(+/-)-(1'S',2'S,3'R)-7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid
CAS No.:1258851-07-8
Molecular Formula:C₁₆H₂₁NO₆
Molecular Weight:323.346
Hs Code.:

Synonyms:(+/-)-(1'S',2'S,3'R)-7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-(1'S',2'S,3'R)-7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid

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Technology Process of (+/-)-(1'S',2'S,3'R)-7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid

There total 2 articles about (+/-)-(1'S',2'S,3'R)-7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 13154-28-4
2-nitrocyclooctanone

: 643-79-8
o-phthalic dicarboxaldehyde

: 7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid

: 1258851-07-8
(+/-)-(1'S',2'S,3'R)-7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid

: 1316054-70-2
(E)-2-[(3-nitro-2-oxocyclooctyliden)methyl]benzaldehyde

Guidance literature:: 2-nitrocyclooctanone; o-phthalic dicarboxaldehyde; With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; dichloromethane; water; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2011.05.115

Reference yield:

: 612-14-6
phthalyl alcohol

: 7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid

: 1258851-07-8
(+/-)-(1'S',2'S,3'R)-7-(1',3'-dihydroxy-2'-nitroindan-2'-yl)heptanoic acid

: 1316054-70-2
(E)-2-[(3-nitro-2-oxocyclooctyliden)methyl]benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate; acetone / 3.5 h / 80 °C

2: water; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethyl acetate; acetone;
DOI:10.1016/j.tet.2011.05.115