N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide

Base Information

Chemical Name:N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide
CAS No.:1231890-82-6
Molecular Formula:C₁₅H₁₂Br₂FNO
Molecular Weight:401.073
Hs Code.:

Synonyms:N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide

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Chemical Property of N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide

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Technology Process of N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide

There total 3 articles about N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 23990-40-1
2-(bromomethyl)-5-fluorobenzoic acid

: 55289-36-6
3-bromo-2-methylaniline

: 1231890-82-6
N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide

Guidance literature:: 2-(bromomethyl)-5-fluorobenzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

3-bromo-2-methylaniline; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00722

Reference yield:

: 55289-36-6
3-bromo-2-methylaniline

: 24138-63-4
2-Brommethyl-5-fluor-benzoyl-chlorid

: 1231890-82-6
N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide

Guidance literature:: 3-bromo-2-methylaniline; 2-Brommethyl-5-fluor-benzoyl-chlorid; In dichloromethane; at 20 ℃; for 1h;

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 33184-16-6
5-fluoro-2-methylbenzoic acid

: 1231890-82-6
N-(3-bromo-2-methylphenyl)-2-(bromomethyl)-5-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 4 h / 78 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.2: 1 h / 20 °C

2.3: 2 h / 20 °C

With N-Bromosuccinimide; oxalyl dichloride; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrachloromethane; dichloromethane;