(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

Base Information

Chemical Name:(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene
CAS No.:162636-76-2
Molecular Formula:C₅₄H₆₉IO₂Si₂
Molecular Weight:933.216
Hs Code.:

(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

Synonyms:(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

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Chemical Property of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

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Technology Process of (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

There total 1 articles about (1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 22-iodo-23,24,25,26,27-pentanor-1α-hydroxyvitamin D₃ 1,3-di-tert-butyldiphenylsilyl ether-SO2 adduct

: 162636-76-2
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

Guidance literature:: With sodium hydrogencarbonate; In ethanol; for 3h; Heating;
DOI:10.1248/cpb.49.312

Reference yield: 83.0%

: 214351-87-8
(3-Methoxymethoxy-3-methyl-butane-1-sulfonyl)-benzene

: 162636-76-2
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

: 336128-28-0
(5E)-23-phenylsulfonyl-1α,25-dihydroxyvitamin D₃ 1,3-di-tert-butyldiphenylsilyl-25-methoxymethyl ether

Guidance literature:: (3-Methoxymethoxy-3-methyl-butane-1-sulfonyl)-benzene; With lithium diisopropyl amide; In tetrahydrofuran; at -20 ℃; for 0.333333h;

(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at -20 ℃; for 2h;
DOI:10.1248/cpb.49.312

Reference yield:

: 162636-76-2
(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-diphenyl-silanyloxy)-2-methylene-cyclohex-(E)-ylidene]-eth-(E)-ylidene]-1-((S)-2-iodo-1-methyl-ethyl)-7a-methyl-octahydro-indene

: 336128-30-4
(6S,8R)-6,8-Bis-(tert-butyl-diphenyl-silanyloxy)-10-[2-[(1R,3aS,7aR)-1-((R)-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-3-methyl-1-oxa-2-aza-spiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / 0.33 h / -20 °C

1.2: 83 percent / HMPA / tetrahydrofuran / 2 h / -20 °C

2.1: 65 percent / 10 percent Na-Hg; MeOH / tetrahydrofuran / 0 °C

3.1: 94 percent / phenyl isocyanate; Et₃N / toluene / 16 h / 20 °C

With methanol; sodium amalgam; phenyl isocyanate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1248/cpb.49.312