2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

Base Information

Chemical Name:2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol
CAS No.:1198211-07-2
Molecular Formula:C₂₃H₂₁ClN₂O
Molecular Weight:376.886
Hs Code.:

Synonyms:2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

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Chemical Property of 2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

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Technology Process of 2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

There total 3 articles about 2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 877-37-2
2-bromo-1-(4-chlorophenyl)-1-propanone

: 1198211-08-3
2-[3-(6-Aminopyridin-3-yl)phenyl]propan-2-ol

: 1198211-07-2
2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

Guidance literature:: 2-bromo-1-(4-chlorophenyl)-1-propanone; 2-[3-(6-Aminopyridin-3-yl)phenyl]propan-2-ol; In propan-1-ol; at 180 ℃; for 0.166667h; Sealed tube; Microwave irradiation;

With propanethiol supported on silica (Biotage Si-Thiol); In propan-1-ol; at 20 ℃; for 6h;

Reference yield:

: 30951-66-7
2-(3-bromophenyl)-2-propanol

: 1198211-07-2
2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere

2.1: propan-1-ol / 0.17 h / 180 °C / Sealed tube; Microwave irradiation

2.2: propanethiol supported on silica (Biotage Si-Thiol) / 6 h / 20 °C

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In propan-1-ol; N,N-dimethyl-formamide;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1198211-07-2
2-{3-[2-(4-chlorophenyl)-3-methylimidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl ether; dibutyl ether; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere

3.1: propan-1-ol / 0.17 h / 180 °C / Sealed tube; Microwave irradiation

3.2: propanethiol supported on silica (Biotage Si-Thiol) / 6 h / 20 °C

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; propan-1-ol; diethyl ether; dibutyl ether; N,N-dimethyl-formamide;