Technology Process of diisopropyl [isothiocyanato(4-methoxyphenyl)methyl]phosphonate
There total 4 articles about diisopropyl [isothiocyanato(4-methoxyphenyl)methyl]phosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.25h;
DOI:10.1016/j.bmcl.2011.05.113
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / ethanol / 3 h / 20 °C
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C
With
hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.113
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / 4 h / 20 °C
2: hydrogenchloride / ethanol / 3 h / 20 °C
3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C
With
hydrogenchloride; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.113
