4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid

Base Information

Chemical Name:4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid
CAS No.:1266100-39-3
Molecular Formula:C₅₀H₅₀N₂O₁₁
Molecular Weight:854.954
Hs Code.:

4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid

Synonyms:4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid

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Chemical Property of 4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid

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Technology Process of 4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid

There total 6 articles about 4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16446-73-4
3-(chlorocarbonyl)phenyl acetate

: 1266100-39-3
4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: 1-amino-3-(dimethylamino)propane / tetrahydrofuran / 3 h / 0 - 20 °C

3: triphenylphosphine; diethylazodicarboxylate / toluene; benzene / 16 h / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5: sodium cyanoborohydride / methanol / 1.25 h / 20 °C

6: sodium hydrogencarbonate / 1,4-dioxane / 1.25 h / 0 °C

With hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; 1-amino-3-(dimethylamino)propane; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; benzene; 3: Mitsunobu reaction;

Reference yield:

: 1264243-44-8,1865786-36-2
tert-butyl (3R,5S)-5-(hydroxymethyl)pyrrolidin-3-ylcarbamate hydrochloride

: 1266100-39-3
4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water

2: triphenylphosphine; diethylazodicarboxylate / toluene; benzene / 16 h / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4: sodium cyanoborohydride / methanol / 1.25 h / 20 °C

5: sodium hydrogencarbonate / 1,4-dioxane / 1.25 h / 0 °C

With hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; water; toluene; benzene; 2: Mitsunobu reaction;

Reference yield:

: 83281-53-2
3-hydroxybenzoic acid allyl ester

: 1266100-39-3
4-(4-((N-((3R,5S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-5-((3-((allyloxy)carbonyl)phenoxy)methyl)pyrrolidin-3-yl)benzamido)methyl)-3,5-dimethoxyphenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene; benzene / 16 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3: sodium cyanoborohydride / methanol / 1.25 h / 20 °C

4: sodium hydrogencarbonate / 1,4-dioxane / 1.25 h / 0 °C

With hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; toluene; benzene; 1: Mitsunobu reaction;