N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea

Base Information

Chemical Name:N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea
CAS No.:1433717-16-8
Molecular Formula:C₂₆H₃₂N₁₀O₃
Molecular Weight:532.605
Hs Code.:

Synonyms:N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea

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Chemical Property of N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea

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Technology Process of N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea

There total 5 articles about N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1391621-83-2
C₂₁H₂₈N₈O

: C₁₂H₁₁N₃O₅

: 1433717-16-8
N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea

Guidance literature:: With sodium hydrogencarbonate; In dimethyl sulfoxide; at 50 ℃;
DOI:10.1016/j.bmc.2013.03.083

Reference yield:

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 1433717-16-8
N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / N,N-dimethyl-formamide; 1,4-dioxane / 4 h / 20 - 80 °C

2: pyridine / 2 h / 20 - 80 °C

3: hydrogen; palladium 10% on activated carbon; hydrogenchloride / methanol; water / 12 h / 20 °C

4: sodium hydrogencarbonate / dimethyl sulfoxide / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In 1,4-dioxane; pyridine; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.03.083

Reference yield:

: 1391621-80-9
benzyl N-[4-(5-amino-1H-3-pyrazolyl)benzyl]carbamate

: 1433717-16-8
N-(5-methyl-3-isoxazolyl)-N'-4-[5-(6-[4-(2-hydroxyethyl)piperazino]-2-methyl-4-pyrimidinylamino)-1H-3-pyrazolyl]benzylurea

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / N,N-dimethyl-formamide; 1,4-dioxane / 4 h / 20 - 80 °C

2: pyridine / 2 h / 20 - 80 °C

3: hydrogen; palladium 10% on activated carbon; hydrogenchloride / methanol; water / 12 h / 20 °C

4: sodium hydrogencarbonate / dimethyl sulfoxide / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In 1,4-dioxane; pyridine; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.03.083