5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

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Chemical Name:5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol
CAS No.:492439-03-9
Molecular Formula:C₂₁H₁₇N₇O
Molecular Weight:383.412
Hs Code.:

Synonyms:5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

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Chemical Property of 5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

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Technology Process of 5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

There total 24 articles about 5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 492438-89-8
[5-(2-Amino-pyrimidin-4-yl)-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-9-yl]-benzyl-amine

: 492439-03-9
5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

Guidance literature:: With sodium thiomethoxide; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/jo026508x

Reference yield: 67.0%

: 492438-96-7
5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-4-methoxy-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine-7-carboxylic acid

: 492439-03-9
5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

Guidance literature:: In diphenylether; at 280 ℃; for 4h;
DOI:10.1021/jo026508x

Reference yield:

: 2-azido-3-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-acrylic acid ethyl ester

: 492439-03-9
5-(2-Amino-pyrimidin-4-yl)-9-benzylamino-pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1.59 g / CH₂Cl₂ / 12 h / 20 °C

2.1: 97 percent / tetrahydrofuran / 24 h / 50 °C

3.1: POCl₃ / CHCl₃ / 0.42 h / 20 °C

3.2: 90 percent / CHCl₃ / 30 h / 70 °C

4.1: 45 percent / dimethylformamide / 110 °C

5.1: 93 percent / K₂CO₃ / 2-methoxy-ethanol / 24 h / Heating

6.1: diphenyl ether / 5 h / 280 °C

7.1: 85 percent / sodium thiomethoxide / dimethylformamide / 3 h / 80 °C

With sodium thiomethoxide; potassium carbonate; trichlorophosphate; In tetrahydrofuran; diphenylether; dichloromethane; chloroform; 2-methoxy-ethanol; N,N-dimethyl-formamide; 1.1: Staudinger reaction;
DOI:10.1021/jo026508x