(3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone

Base Information

Chemical Name:(3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone
CAS No.:1351759-29-9
Molecular Formula:C₁₈H₂₀F₃N₅O₃
Molecular Weight:411.384
Hs Code.:

Synonyms:(3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone

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Chemical Property of (3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone

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Technology Process of (3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone

There total 7 articles about (3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: (4-amino-3-methoxyphenyl)(morpholino)methanone

: 515824-43-8
2-chloro-N-methyl-5-(trifluoromethyl)pyrimidine-4-amine

: 1351759-29-9
(3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 16h;

Reference yield:

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1351759-29-9
(3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; ethanol / 20 °C

2: trifluoroacetic acid / ethyl methyl ether / 18 h / 125 °C

With trifluoroacetic acid; In methanol; ethanol; ethyl methyl ether;
DOI:10.1021/jm300452p

Reference yield:

: 2486-69-3
3-methoxy-4-aminobenzoic acid

: 1351759-29-9
(3-methoxy-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)(morpholino) methanone

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

2: trifluoroacetic acid / ethyl methyl ether / 18 h / 125 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethyl methyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm300452p