Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-methoxy-

Base Information

• Chemical Name: Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-methoxy-
• CAS No.: 90749-83-0
• Molecular Formula: C16H20 N4 O4
• Molecular Weight: 0
• Mol file: 90749-83-0.mol

Synonyms:Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-methoxy-

Chemical Property of Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-methoxy-

Chemical Property:

• PSA: 108.35000
• LogP: 1.13770

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-methoxy-

There total 2 articles about Butanamide, N-(6-amino-1,2,3,4-tetrahydro-3-methyl-2,4-dioxo-1-phenyl-5-pyrimidinyl)-4-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-methoxybutyric acid (29006-02-8) + 5,6-diamino-3-methyl-1-phenyluracil (50786-93-1) → N-(6-Amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-methoxy-butyramide (90749-83-0)

Guidance literature:

1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h;

DOI:10.1016/0223-5234(87)90056-0

Reference yield:

1-phenyl-3-methyl-5-nitroso-6-amino uracil (72702-75-1) → N-(6-Amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-methoxy-butyramide (90749-83-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / H₂ / Raney-NiW-2 / methanol / 4 h / 5320 Torr

2: 64 percent / 1.) 100 deg C, 4 h; 2.) 20 deg C, 20 h

With hydrogen; Raney-NiW-2; In methanol;

DOI:10.1016/0223-5234(87)90056-0

Reference yield: 51.0%

N-(6-Amino-3-methyl-2,4-dioxo-1-phenyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-4-methoxy-butyramide (90749-83-0) → 8-(3-Methoxy-propyl)-1-methyl-3-phenyl-3,7-dihydro-purine-2,6-dione (90749-97-6)

Guidance literature:

With sodium hydroxide; In water; at 100 ℃; for 2h;

DOI:10.1016/0223-5234(87)90056-0

upstream raw materials:

4-methoxybutyric acid

5,6-diamino-3-methyl-1-phenyluracil

1-phenyl-3-methyl-5-nitroso-6-amino uracil

Downstream raw materials:

8-(3-Methoxy-propyl)-1-methyl-3-phenyl-3,7-dihydro-purine-2,6-dione