1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

Base Information

Chemical Name:1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide
CAS No.:896420-89-6
Molecular Formula:C₂₁H₂₃FN₂O₃S
Molecular Weight:402.49
Hs Code.:

Synonyms:1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

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Chemical Property of 1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

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Technology Process of 1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

There total 5 articles about 1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-{[1-Cyclopropyl-meth-(E)-ylidene]-amino}-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

: 896420-89-6
1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

Guidance literature:: With sodium cyanoborohydride; In methanol; dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2006.02.040

Reference yield:

: 3-fluoro-2'-(methylsulfanyl)-1,1'-biphenyl-4-ylamine

: 896420-89-6
1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / 2-ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline; triethylamine / CHCl₃ / 20 h / Heating

2: 89 percent / meta-chloroperbenzoic acid / ethyl acetate / 2.5 h / 20 °C

3: trifluoroacetic acid / CH₂Cl₂ / 1.5 h / 20 °C

4: titanium isopropoxide / CH₂Cl₂ / 1 h / 20 °C

5: 0.21 g / sodium cyanoborohydride / CH₂Cl₂; methanol / 20 h / 20 °C

With titanium(IV) isopropylate; sodium cyanoborohydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane; chloroform; ethyl acetate;
DOI:10.1016/j.bmc.2006.02.040

Reference yield:

: 896420-88-5
1-amino-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

: 896420-89-6
1-(cyclopropylmethyl-amino)-cyclopropanecarboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: titanium isopropoxide / CH₂Cl₂ / 1 h / 20 °C

2: 0.21 g / sodium cyanoborohydride / CH₂Cl₂; methanol / 20 h / 20 °C

With titanium(IV) isopropylate; sodium cyanoborohydride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2006.02.040